A SURVEY OF CELLULAR IMMUNITY, TOTAL T-LYMPHOCYTE, T-ACTIVE , B-LYMPHOCYTE A ND T-CELL FUNCTION IN RELATION TO PHYTOHEMAGGLUTININ (PHA) IN THALASSEMIC PATIENTS

نویسندگان

  • A TABATABAIYAN From the Iranian Blood Transfusion Service, Tehran
  • F TARABADI From the Iranian Blood Transfusion Service, Tehran
  • M IZADYAR the Department of Hematology, Pediatric Medical Center, Tehran University of Medical Sciences, Tehran, I.R. Iran.
  • T ZANDIEH From the Iranian Blood Transfusion Service, Tehran
چکیده مقاله:

The aim of this study was to evaluate the immune system and lymphocyte function in 41 Iranian β-thalassemic patients and 50 controls, ages ranging from 2 to 18 years. The patients consisted of 20 splenectomized and 21 non-splenectomized patients. They were treated with Desferal, and had received repeated blood transfusion. Laboratory investigations included measurement of total T lymphocytes, active T lymphocytes, B-Iymphocytes and function of lymphocytes treated with PHA. In this study we observed a significant reduction of active T lymphocytes and total T lymphocytes in the patient group compared to controls (p<0.005 & p<0.001), but there was no significant difference between splenectomized and non-splenectomized patients. Also in both groups, lymphocyte function was reduced against PHA (phytohemagglutinin) compared with the controls, and the numbers of B cells were increased. These results lead to the conclusion that the deficient immune system in β-thalassemia causes infectious diseases, which finally leads to death. Therefore, stimulation of the immune system as well as clinical treatment may prevent infectious disease in patients with β- thalassemia.

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a survey of cellular immunity, total t-lymphocyte, t-active , b-lymphocyte a nd t-cell function in relation to phytohemagglutinin (pha) in thalassemic patients

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عنوان ژورنال

دوره 16  شماره 3

صفحات  169- 172

تاریخ انتشار 2002-11

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